We estimate for the first time the rate and spectrum of de novo mutations in mice using long-read sequencing, uncovering an important role of indels and transposable element insertions in generating new genetic variation.

The first study on de novo structural mutations (SMs) using long-read sequencing data. Resuts in MA lines of two different strains of C. reinhardtii show that SMs occur at substantial rates. Major differences between the SM spectra can be largely attributed to differences in the spectra of active transposable elements.

An R package for inbreeding and purging analysis on pedigreed populations. The most complete tool for genetic purging analysis to date, including models to estimate individual inbreeding load decline for the first time.