Eugenio López-Cortegano

Statistical Geneticist

Research Direction

I am interested in the evolution of mutational load in populations of small effective size, with a focus on how selection, drift, and mutation shape genome evolution and fitness. My goal is to develop strategies that both inform sustainable breeding practices and contribute to the conservation of genetic resources, ensuring long-term genetic gain while preserving biodiversity.

Download my complete CV.

Interests

Population and Quantitative genetics
Genome architecture
Evolutionary theory
Conservation genetics
Computational biology

Education

PhD in Population Genetics, 2017

Complutense University of Madrid
MSc in Agroforestal Biotechnology, 2012

Technical University of Madrid
BSc in Biology, 2011

Complutense University of Madrid

Featured Publications

January 2025 Genome Research

The rate and spectrum of new mutations in mice inferred by long-read sequencing

We estimate for the first time the rate and spectrum of de novo mutations in mice using long-read sequencing, uncovering an important role of indels and transposable element insertions in generating new genetic variation.

February 2023 Genome Research, 33: 45-60.

Rates and spectra of de novo structural mutations in Chlamydomonas reinhardtii

The first study on de novo structural mutations (SMs) using long-read sequencing data. Resuts in MA lines of two different strains of C. reinhardtii show that SMs occur at substantial rates. Major differences between the SM spectra can be largely attributed to differences in the spectra of active transposable elements.

August 2021 Bioinformatics, 38 (2): 564-565

purgeR: Inbreeding and purging in pedigreed populations

An R package for inbreeding and purging analysis on pedigreed populations. The most complete tool for genetic purging analysis to date, including models to estimate individual inbreeding load decline for the first time.