Inbreeding

Prediction of fitness under different breeding designs in conservation programs
Computer simulations are used to test the estimation of inbreeding-purging parameters in populations under different mating regimes: random mating, circular mating, and equal contributions.
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Genetic purging in captive endangered ungulates with extremely low effective population sizes
We use inbreeding-purging theory to estimate the extent of purging in pedigreed populations of endangered ungulates ($N_e$ < 40). We also derive a mathematical expression to estimate the expected time required for purging to become detectable.
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Genetic purging in captive endangered ungulates with extremely low effective population sizes
purgeR: Inbreeding and purging in pedigreed populations
An R package for inbreeding and purging analysis on pedigreed populations. The most complete tool for genetic purging analysis to date, including models to estimate individual inbreeding load decline for the first time.
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purgeR: Inbreeding and purging in pedigreed populations
Long-term exhaustion of the inbreeding load in Drosophila melanogaster
This work continues previous research on small populations of Drosophila ($N_{e} \approx 50$) for a longer period of time. After more than 100 generations of experiment, the measured inbreeding load is nearly depleted, in agreement with expectations from purging theory.
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purgeR
Estimation of inbreeding-purging genetic parameters in pedigreed populations.
Apr 30, 2021
CRAN
purgeR
Optimal management of genetic diversity in subdivided populations
Genetic diversity maximization in fragmented populations is explored via two different stategies using simulated populations: maximization of allelic diversity, or expected heterozigosity. Our results show that increasing allelic diversity offers a better compromise between reducing populations inbreeding, and preserving the populations adaptive potential
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Optimal management of genetic diversity in subdivided populations
Metapop2
Analysis of gene and allelic diversity in subdivided populations, as well as a tool for management in conservation programs.
Apr 2, 2019
Metapop2
Metapop2: Re-implementation of software for the analysis and management of subdivided populations using gene and allelic diversity
Metapop2 is a reimplementation of the software Metapop, to estimate genic and allelic diversity components in structured populations, and assist in management recommendations (https://gitlab.com/elcortegano/metapop2).
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Metapop2: Re-implementation of software for the analysis and management of subdivided populations using gene and allelic diversity
Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations
An expression to compute ancestral inbreeding ($F_{a}$) as a function of th eeffective population size ($N_{e}$) is derived. Simulations are used to show detection and prediction of purging using models based on $F_{a}$ and purged inbreeding ($g$).
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Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations
Predictive model and software for inbreeding-purging analysis of pedigreed populations
An approximation to compute the purged inbreeding coefficient in pedigrees with overlapping generations is derived, and software to estimate the purging coefficient ($d$) in populations is presented (https://gitlab.com/elcortegano/PURGd).
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Predictive model and software for inbreeding-purging analysis of pedigreed populations