Genetic purging

Prediction of fitness under different breeding designs in conservation programs

Computer simulations are used to test the estimation of inbreeding-purging parameters in populations under different mating regimes: random mating, circular mating, and equal contributions.

Genetic purging in captive endangered ungulates with extremely low effective population sizes

We use inbreeding-purging theory to estimate the extent of purging in pedigreed populations of endangered ungulates ($N_e$ < 40). We also derive a mathematical expression to estimate the expected time required for purging to become detectable.

Genetic purging in captive endangered ungulates with extremely low effective population sizes

purgeR: Inbreeding and purging in pedigreed populations

An R package for inbreeding and purging analysis on pedigreed populations. The most complete tool for genetic purging analysis to date, including models to estimate individual inbreeding load decline for the first time.

purgeR: Inbreeding and purging in pedigreed populations

Long-term exhaustion of the inbreeding load in Drosophila melanogaster

This work continues previous research on small populations of Drosophila ($N_{e} \approx 50$) for a longer period of time. After more than 100 generations of experiment, the measured inbreeding load is nearly depleted, in agreement with expectations from purging theory.

purgeR

Estimation of inbreeding-purging genetic parameters in pedigreed populations.

Apr 30, 2021

purgeR

Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations

An expression to compute ancestral inbreeding ($F_{a}$) as a function of th eeffective population size ($N_{e}$) is derived. Simulations are used to show detection and prediction of purging using models based on $F_{a}$ and purged inbreeding ($g$).

Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations

Predictive model and software for inbreeding-purging analysis of pedigreed populations

An approximation to compute the purged inbreeding coefficient in pedigrees with overlapping generations is derived, and software to estimate the purging coefficient ($d$) in populations is presented (https://gitlab.com/elcortegano/PURGd).

Predictive model and software for inbreeding-purging analysis of pedigreed populations

PURGd

A software to detect purging and to estimate inbreeding-purging genetic parameters in pedigreed populations.

Sep 1, 2016

PURGd

Estimation of genetic purging under competitive conditions

We estimate the extent of inbreeding load and genetic purging in a bottlenecked population of Drosophila melanogaster ($N_{e} \approx 50$) under competitive conditions, and evaluate fitness evolution over 40 generations.

Estimation of genetic purging under competitive conditions