Publications

An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection

我们研究了小鼠大量谱系中突变积累的表型后果，表明新的突变仅产生微弱的影响。

Variation in the spectrum of new mutations among inbred strains of mice

我们验证了以前的小鼠基因组突变率，并证明小鼠品系之间突变谱的变化导致适应度效应分布的差异。

Rates and spectra of de novo structural mutations in Chlamydomonas reinhardtii

The first study on de novo structural mutations (SMs) using long-read sequencing data. Resuts in MA lines of two different strains of C. reinhardtii show that SMs occur at substantial rates. Major differences between the SM spectra can be largely attributed to differences in the spectra of active transposable elements.

Rates and spectra of de novo structural mutations in Chlamydomonas reinhardtii

Prediction of fitness under different breeding designs in conservation programs

计算机模拟用于测试在不同交配方式下种群中近交清除参数的估计：随机交配、循环交配和相等贡献。

Genetic purging in captive endangered ungulates with extremely low effective population sizes

我们使用近亲繁殖-清除理论来估计濒危有蹄类动物（$N_e$ < 40）的纯种种群的清除程度。我们还推导出一个数学表达式来估计清除变为可检测所需的预期时间。

Genetic purging in captive endangered ungulates with extremely low effective population sizes

purgeR: Inbreeding and purging in pedigreed populations

用于近亲繁殖和纯种种群清除分析的 R 包。迄今为止最完整的遗传清除分析工具，包括首次估计个体近交负荷下降的模型。

purgeR: Inbreeding and purging in pedigreed populations

Long-term exhaustion of the inbreeding load in Drosophila melanogaster

这项工作继续了先前对果蝇小种群（$N_{e} \approx 50$）的较长时间的研究。经过 100 多代实验，测得的近亲繁殖负荷几乎耗尽，与清除理论的预期一致。

Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection

人类特征的高度多效性变异在具有强烈背景选择的基因组区域中得到丰富。

De novo mutation rate variation and its determinants in Chlamydomonas

使用来自维持近 1000 代的突变积累系的 WGS 数据，研究 Chlamydomonas reinhardtii 与其已知的最接近的相对 C. incerta 之间的比较可变性。

De novo mutation rate variation and its determinants in Chlamydomonas

Conservation priorities analysis of Chinese indigenous pig breeds in the Taihu lake region

我们分析了太湖猪品种种群内部和种群之间的基因和等位基因多样性如何分布，并提供管理建议。

Conservation priorities analysis of Chinese indigenous pig breeds in the Taihu lake region

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site

使用小鼠的 WGS 数据，我们展示了一种基于观察到的遗传变异和预期位点频谱的自交系突变率的新估计。

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site

Mate choice based on body size similarity in sexually dimorphicpopulations causes strong sexual selection

使用模拟种群，我们展示了当交配受到择偶和偏好偏见的影响时，性别大小二态性如何导致性选择。因此，可能无法仅从性选择数据来估计实践中的配偶选择。

Mate choice based on body size similarity in sexually dimorphicpopulations causes strong sexual selection

Optimal management of genetic diversity in subdivided populations

使用模拟种群通过两种不同的策略探索分散种群中的遗传多样性最大化：等位基因多样性的最大化或预期的杂合性。我们的结果表明，增加等位基因多样性在减少种群近亲繁殖和保持种群适应潜力之间提供了更好的折衷。

Optimal management of genetic diversity in subdivided populations

GWEHS: A Genome-Wide Effect Sizes and Heritability Screener

我们开发了一个工具来处理来自 GWAS Catalog 的数据，并对位点效应大小分布和对遗传力的贡献进行分析。该工具可通过交互式网站 (http://gwehs.uvigo.es) 和 docker 图像访问。

GWEHS: A Genome-Wide Effect Sizes and Heritability Screener

Inferring the nature of missing heritability in human traits using data from the GWAS Catalog

使用来自 GWAS Catalog 的数据，我们推断基因座效应大小遵循对数正态分布，并且许多数量性状的遗传力差距可能永远不会关闭。

Inferring the nature of missing heritability in human traits using data from the GWAS Catalog

Metapop2: Re-implementation of software for the analysis and management of subdivided populations using gene and allelic diversity

Metapop2 是软件 Metapop 的重新实现，用于估计结构化种群中的基因和等位基因多样性成分，并协助管理建议（https://gitlab.com/elcortegano/metapop2）。

Metapop2: Re-implementation of software for the analysis and management of subdivided populations using gene and allelic diversity

Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations

导出计算祖先近亲繁殖 ($F_{a}$) 作为有效种群大小 ($N_{e}$) 的函数的表达式。模拟用于显示使用基于 $F_{a}$ 和清除近亲繁殖 ($g$) 的模型检测和预测清除。

Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations

Predictive model and software for inbreeding-purging analysis of pedigreed populations

推导出具有重叠世代的谱系中清除近交系数的近似值，并提供了估计种群中清除系数 ($d$) 的软件 (https://gitlab.com/elcortegano/PURGd)。

Predictive model and software for inbreeding-purging analysis of pedigreed populations

Estimation of genetic purging under competitive conditions

我们估计了在竞争条件下 Drosophila melanogaster ($N_{e}\approx 50$) 的瓶颈种群的近交负荷和遗传清除的程度，并评估了 40 代以上的适应性进化。

Estimation of genetic purging under competitive conditions